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目的 :探讨高血压颈动脉内 中膜增厚 (IMT)与血浆内皮素 (ET)之间的关系。方法 :多普勒超声诊断仪检测 93例原发性高血压 (EH)患者 (1级高血压 2 9例 ,2级高血压 38例 ,3级高血压 2 6例 )与 32例正常对照者的颈动脉IMT ,放射免疫法检测血浆ET。结果 :与正常对照组比较 ,EH组颈动脉IMT增厚 ,以 2、3级EH患者明显 ,血浆EH升高 ,IMT与ET呈正相关 (r =0 .0 6 9,P <0 .0 1)。结论 :ET可能参与EH颈动脉IMT的发生、发展过程
Objective: To investigate the relationship between hypertensive carotid intima-media thickness (IMT) and plasma endothelin (ET). Methods: Ninety-three patients with essential hypertension (29 with grade 1 hypertension, 38 with grade 2 hypertension and 26 with grade 3 hypertension) and 32 normal controls were examined by Doppler ultrasonography. Of carotid IMT, radioimmunoassay of plasma ET. Results: Compared with the normal control group, the carotid IMT in EH group was thicker, and the level of EH was obviously higher in patients with grade 2 and 3 than in normal control group, and the plasma EH was increased. There was a positive correlation between IMT and ET (r = 0.609, P0.01 ). Conclusion: ET may be involved in the occurrence and development of EH carotid IMT