目的:探讨泮托拉唑治疗消化性溃疡合并上消化道出血的疗效。方法:回顾性分析我院2012年7月~2015年7月我院收治的消化性溃疡合并上消化道出血患者80例的临床资料,随机分为对照组和观察组,对照组采取奥美拉唑治疗,观察组采取泮托拉唑治疗,比较两组患者的临床疗效。结果:观察组治疗第1d、第3d,出血量明显低于对照组,差异有统计学意义(P<0.05)。观察组总有效率为95%,对照组总有效率为85%,观察组临床疗效显著优于对照组,差异有显著性(P<0.05)。结论:泮托拉唑治疗消化性溃疡合并上消化道出血的疗效显著,不良反应较小,安全性较高,值得在临床上推广应用。 Objective: To investigate the efficacy of Pantoprazole in the treatment of peptic ulcer with upper gastrointestinal bleeding. Methods: A retrospective analysis of our hospital from July 2012 to July 2015 in our hospital admitted peptic ulcer patients with upper gastrointestinal bleeding in 80 cases of clinical data were randomly divided into control group and observation group, the control group to adopt Omer Azole treatment, the observation group to take pantoprazole treatment, the clinical efficacy of two groups were compared. Results: The bleeding volume in the observation group was significantly lower than that in the control group on the 1st and 3rd days after treatment (P <0.05). The total effective rate was 95% in the observation group and 85% in the control group. The clinical efficacy of the observation group was significantly better than that of the control group (P <0.05). Conclusion: Pantoprazole is effective in treating peptic ulcer with upper gastrointestinal bleeding, with less adverse reactions and higher safety. It is worth to be popularized clinically.