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目的探讨在甲状腺功能减退中采用甲状腺片联合左甲状腺素钠片治疗的临床效果。方法选取2014年7月—2016年7月河南省人民医院收治的156例甲状腺功能减退患者,按照治疗顺序随机分为对照组和试验组,每组78例。对照组采用甲状腺片治疗,试验组在对照组基础上加用优甲乐治疗。对比两组患者的治疗有效率、治疗前后的血清指标情况以及指标恢复的时间。结果试验组治疗有效率为98.72%,对照组为88.46%,组间差异有统计许意义(P<0.05)。两组治疗前各项血清指标比较,差异无统计学意义(P>0.05);两组治疗前后差异均有统计学意义(P<0.05);试验组治疗后各项血清指标改善情况优于对照组,差异有统计学意义(P<0.05)。试验组血清TSH指标的恢复时间为(5.84±2.71)周,对照组为(9.63±3.68)周,两组差异有统计学意义(P<0.05)。结论在甲状腺功能减退中采用甲状腺片联合左甲状腺素钠片治疗的临床效果较好,可以快速恢复患者血清指标,治疗有效率也比较高,无明显不良反应,可以在临床上进行推广应用。
Objective To investigate the clinical effect of thyroid tablets combined with levothyroxine sodium in hypothyroidism. Methods From July 2014 to July 2016, 156 cases of hypothyroidism admitted to Henan Provincial People’s Hospital were randomly divided into control group and experimental group according to the treatment sequence, with 78 cases in each group. The control group was treated with thyroid tablets, and the experimental group was treated with Euthyrox on the basis of the control group. The two groups of patients were compared with the treatment efficiency, serum indicators before and after treatment and indicators of recovery time. Results The effective rate was 98.72% in the experimental group and 88.46% in the control group, with statistical significance (P <0.05). There was no significant difference in each serum index between the two groups before treatment (P> 0.05). The difference between the two groups before and after treatment was statistically significant (P <0.05). The improvement of each serum index in the experimental group after treatment was better than that in the control Group, the difference was statistically significant (P <0.05). The recovery time of serum TSH index was (5.84 ± 2.71) weeks in the experimental group and (9.63 ± 3.68) weeks in the control group, the difference was statistically significant (P <0.05). Conclusions The thyroxine combined with levothyroxine sodium tablets has a good clinical effect in the treatment of hypothyroidism, which can rapidly restore the serum indexes of patients. The treatment efficiency is relatively high, with no obvious adverse reactions and can be popularized and applied clinically.