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目的探讨老年呼吸困难患者血浆脑钠肽(BNP)水平及在鉴别诊断中的价值。方法选择我院老年出现呼吸困难的患者,通过各项检查明确为心源性呼吸困难组及非心源性呼吸困难组,检测血浆BNP和心脏超声。心源性呼吸困难组根据心脏超声LVEF分为心源性呼吸困1难组和心源性呼吸困难2组。结果心源性呼吸困难组血浆BNP浓度较非心源性呼吸困难组显著升高(P<0.01),心源性呼吸困难LVEF的各亚组患者BNP水平间差异均有统计学意义(P<0.05),且与LVEF负相关(r=-0.34,P<0.001)。结论血浆BNP测定是老年呼吸困难患者鉴别诊断标志物。
Objective To investigate the level of plasma brain natriuretic peptide (BNP) in elderly patients with dyspnea and its value in the differential diagnosis. Methods Patients with dyspnea in our hospital were selected. Plasma BNP and echocardiography were detected by various examinations in patients with cardiogenic dyspnea and noncardiogenic dyspnea group. Cardiac dyspnea group was divided into two groups according to cardiac ultrasound LVEF: cardiogenic dyspnea group 1 and cardiogenic dyspnea group. Results Plasma BNP levels in patients with cardiogenic dyspnea group were significantly higher than those in noncardiogenic dyspnea group (P <0.01). BNP levels in all subgroups of patients with cardiogenic dyspnea were statistically significant (P < 0.05), and negatively correlated with LVEF (r = -0.34, P <0.001). Conclusion Plasma BNP is a differential diagnosis marker for elderly patients with dyspnea.