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目的:探讨依达拉奉联合化痰通络组方对脑梗死患者血脂、颈动脉内-中膜厚度及复发率的影响。方法:选取2014年5月至2015年5月河北燕达医院收治96例合并有高血脂症和颈动脉粥样硬化的脑梗死患者,随机将其分为对照组和治疗组,每组48例,对照组患者在脑梗死常规治疗上予以化痰通络方治疗,治疗组在对照组基础上联合依达拉奉治疗,分别观察比较两组患者治疗前与治疗3个月、6个月、9个月后的血脂、颈动脉内-中膜厚度及复发率。结果:(1)在治疗后各相应时间段治疗组的三酰甘油、低密度脂蛋白水平较对照组及治疗前均明显较低,在治疗9个月后,高密度脂蛋白水平高于治疗前及对照组,差异具有统计学意义(P<0.05);(2)治疗6个月、9个月后,两组患者颈动脉内-中膜厚度较治疗前低,且治疗组明显低于对照组,比较差异具有统计学意义(P<0.05);(3)观察治疗至9个月时,对照组脑梗死复发率16.7%明显高于治疗组4.2%,组间比较,差异具有统计学意义(P<0.05)。结论:依达拉奉联合化痰通络方治疗脑梗死不仅能明显降低患者血脂水平,减低颈动脉内-中膜厚度,还大大降低脑梗死患者的复发率。
Objective: To investigate the effect of Edaravone and Huatan Tongluo Prescription on serum lipids, carotid intima-media thickness and recurrence in patients with cerebral infarction. Methods: From May 2014 to May 2015, 96 patients with cerebral infarction complicated with hyperlipidemia and carotid atherosclerosis were treated in Hebei Yanda Hospital and randomly divided into control group and treatment group, with 48 cases in each group The patients in the control group were treated with Huatan Tongluo Formula in the routine treatment of cerebral infarction. The treatment group was treated with edaravone on the basis of the control group. The patients in both groups were observed before treatment and 3 months and 6 months respectively, Blood lipids, carotid IMT thickness and relapse rate after 9 months. Results: (1) After treatment, the levels of triglyceride and low density lipoprotein in the treatment group were significantly lower than those in the control group and before treatment. After 9 months of treatment, the levels of high density lipoprotein were higher than those in the treatment group (P <0.05). (2) After 6 months and 9 months of treatment, the carotid artery intima-media thickness in both groups was lower than that before treatment and the treatment group was significantly lower than the control group (P <0.05). (3) When the treatment was 9 months, the recurrence rate of cerebral infarction in control group was significantly higher than that in treatment group (16.7% vs 4.2%). There was statistical difference between two groups Significance (P <0.05). Conclusion: Edaravone combined with Huatan Tongluo Recipe in treatment of cerebral infarction can not only significantly reduce the level of serum lipids, reduce the thickness of carotid intima - media, but also greatly reduce the recurrence rate of patients with cerebral infarction.