【摘 要】
：
为了寻求新颖的抗糖尿病药物,我们将芳香醛、对溴苯乙酮和磺胺嘧啶通过一步反应直接合成了16个未见报道的含有磺胺嘧啶结构的β-氨基酮化合物,制备方法简便、反应条件温和,收
【机 构】
：
西南大学化学化工学院,成都地奥制约集团有限公司药物筛选中心
论文部分内容阅读
为了寻求新颖的抗糖尿病药物,我们将芳香醛、对溴苯乙酮和磺胺嘧啶通过一步反应直接合成了16个未见报道的含有磺胺嘧啶结构的β-氨基酮化合物,制备方法简便、反应条件温和,收率为10.0%~80.1%.所制备的化合物通过~1H NMR,~(13)C NMR,,MS和HRMS进行结构表征与确证.对这些化合物进行αa-葡萄糖苷酶抑制活性初步检测,结果表明部分化合物在低浓度范围(8.1～9.3 nmol·mL~(-1))具有一定的α-葡萄糖苷酶抑制活性.
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