CD40L高表达在急性冠脉综合症病人中的临床意义

来源 :中华医学杂志 | 被引量 : 0次 | 上传用户：xzm191213

【摘要】

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目的探讨急性冠脉综合症(ACS)病人外周血单核细胞表达CD40L及血清可溶性CD40L(sCD40L) 变化的临床意义.方法应用流式细胞术和ELISA分别对正常对照组16例、稳定心绞痛24例、不

【作者】

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严金川吴宗贵黄佐李莉仲人前孔宪涛

【机构】

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第二军医大学附属长征医院心内科,第二军医大学附属长征医院实验科

【出处】

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中华医学杂志

【发表日期】

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2004年期

【关键词】

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CD40配体急性冠脉综合症动脉粥样硬化 CD40 ligand acute coronary syndromes atherosclerosis

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目的探讨急性冠脉综合症(ACS)病人外周血单核细胞表达CD40L及血清可溶性CD40L(sCD40L) 变化的临床意义.方法应用流式细胞术和ELISA分别对正常对照组16例、稳定心绞痛24例、不稳定心绞痛20例、急性心肌梗死12例患者血单核细胞表达CD40L及血清可溶性sCD40L水平进行检测.结果 UA组及AMI组血单核细胞表达CD40L及血清sCD40L水平明显较SA和对照组高(P0.05),但AMI发病后24小时sCD40L有一峰值.PTCA后血清sCD40L明显高于PTCA前(P0.05).结论血清可溶性CD40L升高是判断ACS的可靠血清学指标,且可能是冠脉病变的活动性标志物.

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CD40L高表达在急性冠脉综合症病人中的临床意义

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