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目的探讨乳腺癌组织钙离子结合蛋白S100A4、EZH2蛋白的表达变化及与患者临床病理特征的关系。方法选择该院2008-2014年收治的87例诊疗、随访资料完整的乳腺癌患者作为病例组,选取该院病理科收集的30例健康妇女乳腺组织标本作为健康组,采用免疫组化法检测两组标本中S100A4、EZH2蛋白表达情况;统计分析S100A4、EZH2蛋白表达与患者临床病理特征的关系。结果病例组的S100A4阳性率为80.46%、EZH2阳性率为78.16%均显著高于健康组的19.54%、21.84%,且差异均具有统计学意义(P<0.05)。乳腺癌患者的S100A4阳性表达与患者是否发生淋巴结转移、组织学分级程度具有显著的关系(P<0.05);EZH2的阳性表达与患者的是否发生淋巴结转移、组织学分级程度、TNM分期具有显著的关系(P<0.05)。结论乳腺癌组织S100A4、EZH2蛋白的表达增强,同时与患者的淋巴结转移、临床分析、组织学分级具有一定的关系。
Objective To investigate the expression changes of S100A4 and EZH2 protein in breast cancer and its relationship with clinicopathological features. Methods A total of 87 cases of patients with breast cancer who were diagnosed and treated in our hospital from 2008 to 2014 were selected as the case group. Thirty healthy women ’s breast tissues collected from the hospital were selected as healthy group. Immunohistochemistry The expression of S100A4 and EZH2 in the group of samples were analyzed statistically. The relationship between the expression of S100A4 and EZH2 protein and clinicopathological features were analyzed statistically. Results The positive rate of S100A4 and the positive rate of EZH2 in case group were 80.46% and 78.16%, respectively, which were significantly higher than those in healthy group (19.54% and 21.84%, respectively) (P <0.05). The positive expression of S100A4 in breast cancer patients was positively correlated with lymph node metastasis and histological grade (P <0.05). The positive expression of EZH2 in patients with lymph node metastasis, histological grade and TNM stage had significant Relationship (P <0.05). Conclusion The expression of S100A4 and EZH2 protein in breast cancer tissues is enhanced, and it also has certain relationship with lymph node metastasis, clinical analysis and histological grade.