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目的 观察和分析脑肿瘤患者血清中肿瘤相关物质(TSGF)的诊断价值和临床意义。方法 留取脑肿瘤患者血清标本,使血清中TSGF与显色剂显色反应,测其吸光度,查标准曲线,求出TSGF含量,并设健康组作对照。结果 88例脑肿瘤患者血清TSGF、含量(72.3±10.1)高于健康对照组(50.4±8.5),P<0.05。其中恶性脑肿瘤患者血清。TSGF含量(82.3±8.7)显著高于良性脑肿瘤患者TSGF含量(58.7±8.4),P<0.01。48例恶性脑肿瘤患者术后血清TSGF含量(58.9±9.3)显著低于术前(P<0.05)。且TSGF含量变化与恶性肿瘤术后早期复发存在密切关系。结论 TSGF作为肿瘤标志物,在脑肿瘤的良恶性鉴别、恶性度评估、预后预测和脑部恶性肿瘤的辅助诊断等方面具有重要临床意义,对预示恶性脑肿瘤术后早期复发有一定作用。
Objective To observe and analyze the diagnostic value and clinical significance of serum tumor related substances (TSGF) in patients with brain tumors. Methods Serum samples from patients with brain tumor were collected, and the colorimetric reaction of TSGF and chromogenic reagent was performed. The absorbance was measured and the standard curve was checked. The content of TSGF was calculated and compared with the healthy group. Results The serum TSGF levels in 88 patients with brain tumor (72.3 ± 10.1) were significantly higher than those in healthy controls (50.4 ± 8.5), P <0.05. Malignant brain tumor patients serum. TSGF content of 82.3 ± 8.7 was significantly higher than that of benign brain tumors (58.7 ± 8.4) (P <0.01). The postoperative TSGF content of 58 malignant brain tumors (58.9 ± 9.3) was significantly lower than that of preoperative (P < 0.05). The change of TSGF content is closely related to the early recurrence of malignant tumor. Conclusion As a tumor marker, TSGF has important clinical significance in differentiating benign and malignant brain tumors, evaluating malignancy, predicting prognosis and assisting diagnosis of malignant brain tumors. It is indicated that TSGF may play an important role in early postoperative recurrence of malignant brain tumors.