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目的 探讨大肠癌浆膜侵犯螺旋CT征象与MVD及nm2 3 H1表达间的关系。方法 对 4 2例螺旋CT征象上不同浸润深度的大肠癌组织采用SP免疫组化法进行nm2 3 H1表达的检测 ,并计数MVD。结果 在螺旋CT征象上浆膜侵犯有、无组 ,MVD比较有统计学意义 (t’ =- 2 .85 2 ,P =0 .0 0 7) ,两组nm2 3 H1的阳性表达无统计学意义 (χ2 =0 .318,P =0 .710 ) ,nm2 3 H1表达阳性组和阴性组的MVD比较有统计学意义 (t=- 2 .14 9,P =0 .0 38)。结论 血管生成可能在大肠癌浸润生长中起促进作用 ;nm2 3 H1可能是肿瘤血管生成的抑制因子 ;螺旋CT征象上显示癌肿肠周脂肪层有线样、条索状高密度影并不一定提示其具有更高的远处转移倾向。
Objective To investigate the relationship between spiral CT features and the expression of MVD and nm23 H1 in colorectal carcinoma. Methods The expression of nm23 H1 was detected by SP immunohistochemistry in 42 invasive specimens of colorectal cancer with different depth of invasion. The MVD was counted. Results Serosal invasion was associated with helical CT signs, with no group and MVD was statistically significant (t ’= -2.852, P = 0.076). The positive expression of nm23 H1 in the two groups was not statistically significant (χ2 = 0.318, P = 0.710). The MVD of nm23 H1 -positive and negative groups was statistically significant (t = -2.249, P = 0.038). Conclusion Angiogenesis may play an important role in the invasion and growth of colorectal cancer. Nm23 H1 may be an inhibitor of tumor angiogenesis. Spiral CT findings show that there is linear and cord-like hyperplasia in the peritoneal fat layer of the cancer It has a higher tendency of distant metastasis.