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目的和方法 为探讨蛛网膜下腔出血（ＳＡＨ）不同时期血与脑脊液中一氧化氮（ＮＯ）含量变化的临床意义；送检１４ 例ＳＡＨ 不同时期血清与脑脊液，采用Ｇｒｅｅｎ 改良法检测ＮＯ含量，并配有３０ 例血清的正常对照。结果 ＳＡＨ 血清中ＮＯ均较对照组低，尤以第２ 周为著；脑脊液中ＮＯ含量第２ 周最低，第３ 周含量高于第１周；ＳＡＨ的出血量多少与血和脑脊液中ＮＯ含量呈负相关。结论 ＳＡＨ 的ＮＯ的含量变化说明，ＮＯ减少是ＳＡＨ的脑血管痉挛的原因之一
Objective and Methods To investigate the clinical significance of the changes of nitric oxide (NO) content in blood and cerebrospinal fluid (CSF) in different stages of subarachnoid hemorrhage (SAH), to examine the serum and cerebrospinal fluid (CSF) in 14 cases of SAH at different stages, And with 30 cases of serum normal control. Results NO in SAH serum was lower than that in control group, especially in the second week. The content of NO in cerebrospinal fluid was the lowest in the second week and the content in the third week was higher than that in the first week. The amount of SAH in the blood was correlated with the content of NO in blood and cerebrospinal fluid Negative correlation. Conclusions The change of NO content in SAH indicates that NO reduction is one of the causes of cerebral vasospasm in SAH