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本文以人外周血淋巴细胞为实验材料，在血样培养至３８ｈ时给予不同浓度（０．０１～０．１μｇ／ｍＬ）丝裂霉素Ｃ（ＭＭＣ）作预先处理，４ｈ后再给予１．５ＧｙＸ射线照射，以观察化学物质和电离辐射的交叉抗性。结果表明，当ＭＭＣ处理浓度分别为０．０５，０．０７５μｇ／ｍＬ和０．０１μｇ／ｍＬ时，染色体畸变率和姊妹染色单体互换（ＳＣＥ）频率分别明显低于预期值；而当ＭＭＣ预处理浓度为０．０５、０．０７５、０．１０μｇ／ｍＬ时微核发生率明显高于预期值。提示在研究化学物质与电离辐射的交叉抗性时，不同观察指标结论可能不一致。
In this study, human peripheral blood lymphocytes were used as experimental materials, mitomycin C (MMC) with different concentrations (0.01 ~ 0.1μg / mL) were pretreated at 38h after blood culture and 1.5GyX Radiation exposure to observe cross-resistance of chemicals and ionizing radiation. The results showed that the frequencies of chromosomal aberrations and sister chromatid exchange (SCE) were significantly lower than those expected when the MMC concentrations were 0.05, 0.075 μg / mL and 0.01 μg / mL, respectively. When MMC The pre-treatment concentration of 0.05,0.075,0.10μg / mL micronucleus incidence was significantly higher than expected. It is suggested that the conclusions of different observation indexes may be inconsistent when studying the cross resistance between chemical substances and ionizing radiation.