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目的探讨影响原发性输尿管癌患者生存的预后因素。方法回顾性分析48例原发性输尿管癌患者资料,采用Kaplan—Meier法和Cox回归法分析各因素对预后的影响。结果患者平均随访31个月(3—129个月),48例患者中,18例死亡,患者1年生存率为77.0%,3年生存率为64.9%,5年生存率为54.1%。单因素分析结果显示:年龄、性别、临床分期、肿瘤位置、腰痛、肉眼血尿、中性粒细胞与淋巴细胞比值(NLR)与原发性输尿管癌患者的预后有关(P<0.05)。Cox多因素分析结果显示:临床分期、年龄、NLR是影响原发性输尿管癌患者预后的独立预后因素(P<0.05)。结论在原发性输尿管癌患者中,临床分期越高、年龄越大、NLR越大,患者的预后越差。
Objective To explore the prognostic factors that affect the survival of patients with primary ureteral cancer. Methods The data of 48 patients with primary ureteral carcinoma were retrospectively analyzed. The effects of various factors on the prognosis were analyzed by Kaplan-Meier method and Cox regression analysis. Results The patients were followed up for an average of 31 months (3-129 months). Of the 48 patients, 18 died. The 1-year survival rate was 77.0%. The 3-year survival rate was 64.9% and the 5-year survival rate was 54.1%. Univariate analysis showed that age, gender, clinical stage, tumor location, low back pain, gross hematuria, neutrophil and lymphocyte ratio (NLR) were associated with the prognosis of patients with primary ureteral cancer (P <0.05). Cox multivariate analysis showed that clinical stage, age, and NLR were independent prognostic factors in patients with primary ureteral carcinoma (P <0.05). Conclusion In patients with primary ureteral cancer, the higher the clinical stage, the older the larger the NLR, the worse the prognosis of the patients.