论文部分内容阅读
利福喷丁(rifapentine,R773)是我国近年研制的新型长效利福霉素。国内外曾报道利福平在人体内能加速自身及其他若干种药物的代谢。作为同类衍生物,利福喷丁可能也具有肝微粒体酶诱导作用,本文报道了这方面的动物实验结果。 利福喷丁处理对小鼠肝重的影响 昆明小鼠?,体重18±SD2g,随机分为4组,每组10只,对照组每两天ig一次1％甲基纤维素溶液(R773的溶剂)0.2ml/只;其余3组分别igR773 10,20和40mg/kg,隔日一次,共给药15d。结果各组小鼠的相对肝脏重量(肝重占体重的百分比)依次为:对照组4.8±SD0.4％;R77310mg/kg组5.5±0.4％;
Rifapentine (R773) is a new long-acting rifamycin developed in recent years in China. Domestic and foreign reports have reported that rifampicin can accelerate the metabolism of itself and several other drugs in the human body. As a similar derivative, rifapentine may also have liver microsomal enzyme induction, this article reports the results of animal experiments. Effects of rifapentine treatment on liver weight in mice Kunming mice, weighing 18 ± SD2g, were randomly divided into 4 groups with 10 rats in each group. The control group was treated with 1% methylcellulose solution every two days (R773 Solvent) 0.2ml / only; the remaining three groups were igR773 10,20 and 40mg / kg, every other day for a total of 15d. Results The relative liver weights (percentage of liver weight) of mice in each group were as follows: 4.8 ± SD 0.4% in the control group, 5.5 ± 0.4% in the R77310 mg / kg group,