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目的了解蓬莱市健康人群发热伴血小板减少综合征布尼亚病毒(SFTSV)感染情况,并分析其分布规律及流行因素,为控制疫情提供理论依据。方法采用多阶段整群随机抽样方法抽取健康人群1 525人,采集其血液标本并分离血清,采用间接酶联免疫吸附实验(ELISA)检测人群中新布尼亚病毒特异性Ig G抗体,并采用统计学方法对不同年龄组人群、不同时间采集人群血清抗体阳性率进行比较。结果 1 525人份血清中,新布尼亚病毒特异性Ig G抗体阳性138份,阳性率为9.05%,男性人群抗体阳性率为9.28%(61/657),女性抗体阳性率为8.87%(77/868),两者差异无统计学意义(χ2=0.078,P>0.05)。各年龄组人群均有感染,以61~70岁年龄组人群新布尼亚病毒抗体阳性率最高,各年龄组人群抗体阳性率组间的差异具有统计学意义(χ2=46.86,P<0.05),农民抗体阳性率明显高于学生(χ2=6.45,P<0.05),流行后期人群抗体阳性率高于流行期人群抗体水平(χ2=9.36,P<0.01)。结论蓬莱市健康人群中发热伴血小板减少综合征布尼亚病毒抗体阳性率较高,提示大多数SFTSV病毒感染后宿主体内产生的抗体可能会持续较长时间,为我们了解疾病的发生、发展规律提供了基础的理论数据。该病毒在蓬莱市流行强度较强,应引起高度重视。
Objective To understand the incidence of feverish with thrombocytopenic syndrome Bunyavirus (SFTSV) in healthy population in Penglai city and analyze its distribution and epidemic factors to provide a theoretical basis for controlling the epidemic. Methods A total of 1 525 healthy volunteers were recruited by multistage cluster random sampling method. Blood samples were collected and serum was separated. Nebrandinia virus-specific Ig G antibody was detected by indirect enzyme-linked immunosorbent assay (ELISA) The statistical methods were used to compare the positive rates of serum antibodies among different age groups and different time groups. Results Among the 1 525 serum samples, 138 were positive for New Bunyan virus-specific Ig G antibody, the positive rate was 9.05%. The positive rate of antibody in male population was 9.28% (61/657) and the positive rate of female antibody was 8.87% 77/868), the difference was not statistically significant (χ2 = 0.078, P> 0.05). In all age groups, there was infection in the population. The positive rate of New Bunyavirus antibody in the population of 61-70 years old was the highest, and there was a significant difference between the antibody positive rate groups in all age groups (χ2 = 46.86, P <0.05) (Χ2 = 6.45, P <0.05). The positive rate of antibody in peasants was higher than that in epidemic population (χ2 = 9.36, P <0.01). Conclusion The positive rate of fever virus with thrombocytopenia syndrome Bunyavirus antibody in healthy population in Penglai City suggests that most of the antibodies produced by the host after SFTSV virus infection may last a long time, which may help us understand the occurrence and development of disease Provided the basic theoretical data. The virus epidemic in Penglai City, strong, should be given high priority.