类风湿关节炎(rheumatoid arthritis,RA)是一种以慢性破坏性关节病变为特征的全身性自身免疫病〔1〕。具有高发性、高致残性等特点,其病理特征为慢性滑膜炎,发病2年内即可发生不可逆性的关节损害,严重影响人们的生活质量,早期诊断和治疗是减少和阻止病情发展及防止致残的关键。因此,在临床中要有高敏感性、高特异性的实验室检测指标和诊断方法,有助于评价疾病的活动性及预后,为的早期诊断提供可靠依据。患者 Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic devastating joint disease [1]. With high incidence, high disability characteristics, the pathological features of chronic synovitis, the incidence of irreversible joint damage can occur within 2 years, seriously affecting people’s quality of life, early diagnosis and treatment is to reduce and prevent the progression of the disease and The key to prevent disability. Therefore, in the clinic to have high sensitivity, high specificity of laboratory test indicators and diagnostic methods, contribute to the evaluation of disease activity and prognosis, provide a reliable basis for the early diagnosis. patient