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目的:了解国家基本药物致儿童药品不良反应(ADR)情况,促进儿科合理用药。方法:对百色市ADR监测中心2011年406例儿童ADR报告中涉及国家基本药物所致的237例ADR报告,按性别、年龄、给药途径、报告类型、基本药物类别、ADR涉及器官或系统及临床表现等进行统计、分析。结果:3岁以下儿童ADR发生率最高,占44.73%;静脉给药方式是引发ADR的主要途径,占80.89%;以抗微生物药引发ADR最多,占66.67%;ADR最常见的临床表现为皮肤及其附件损害,占58.56%。结论:应重视基本药物致儿童ADR的报告和监测工作,以减少或避免ADR的发生,保障患儿用药安全。
Objective: To understand the state of essential medicines caused by children’s adverse drug reactions (ADR), promote the rational use of medicines. Methods: A total of 237 ADR cases involving 406 cases of ADR reported by the ADR monitoring center of Baise City in 2011 were analyzed by sex, age, route of administration, report type, essential drug category, organs or systems involved in ADR, Clinical performance statistics, analysis. Results: The incidence of ADR was the highest in children under 3 years old, accounting for 44.73%. The main route of ADR was intravenous administration, accounting for 80.89%. The most ADR was antimicrobial drug, accounting for 66.67%. The most common clinical manifestation of ADR was skin And its annex damage, accounting for 58.56%. Conclusion: The reporting and monitoring of ADR in children caused by essential drugs should be emphasized in order to reduce or avoid the occurrence of ADR and ensure the safety of children’s medication.