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目的:探讨慢性乙型肝炎(CHB)和乙型肝炎后肝硬化患者血清中的基质金属蛋白酶(MMP-1)变化及其临床意义。方法:选择我院2007-02/2008-04收住院的慢乙肝患者127例,按病情分为慢性轻度,慢性中度,慢性重度,肝硬化四组。MMP-1检测采用双抗体夹ABC-ELISA法(试剂盒由上海西唐生物科技有限公司提供)。结果:随着肝脏炎症程度和纤维化程度的增加,血清MMP-1的值越来越降低,慢中组与慢轻组比较,慢重组与慢中组比较,肝硬化组与慢重组比较均有统计学意义,P<0.05。结论:MMP-1对评价肝脏炎症程度及纤维化程度有一定意义。
Objective: To investigate the changes of serum matrix metalloproteinase (MMP-1) in patients with chronic hepatitis B (CHB) and post-hepatitis B cirrhosis and its clinical significance. Methods: A total of 127 chronic hepatitis B patients admitted to our hospital from February 2007 to April 2008 were divided into four groups: chronic mild, chronic moderate, chronic severe and cirrhosis. MMP-1 detection using double antibody sandwich ABC-ELISA method (Kit from Shanghai Xitang Biotechnology Co., Ltd.). Results: With the increase of hepatic inflammation and fibrosis, the serum MMP-1 level decreased more and more. Compared with slow-light group, There was statistical significance, P <0.05. Conclusion: MMP-1 is of certain significance in evaluating the degree of liver inflammation and fibrosis.