Objective:An attempt was made to study the use of papaya pulp powder as a disintegrant in tablet formulations. The objective of the present work is to identify a natural binding and disintegrating agent for formulating tablets and to study the effect of disintegrating agents and binding agents on the dissolution of the formulation containing paracetamol.Methods:Papaya pulp powder is obtained from unripe papaya fruit.The fruit was screened for its physical and chemical characteristics and used in tablet formulations.In order to find out the percentage that could be used to formulate a product containing good disintegrating and dissolution characteristics, several formulations(Paracetamol) with different concentrations of 8%,10%,12%,15%,20%,25%& 30%were prepared.As a comparison,an already established disintegrant,sodium starchgylcolate was selected and several formulations containing similar concentrations,were also prepared.The invitro evaluation of the formulations were undertaken,and the results compared.In the present study preformulation studies on the purity, development of calibration curve of the drug and the compatibility between the drug and excepients were carried out.The fruits were cut into small pieces,grated,dried and powdered,passed through different sieves and made into fine powder.Fine powder of papaya was mixed with required amount of drug and sodium starchgylcolate individually in different concentrations along with other additives & binding agents.The dried granules were compressed into tablets and all the formulated dosage forms of paracetamol tablets were subjected to quality control tests like hardness disintegration and dissolution.Results:From the results it was observed that formulations S1 and P7 containing 8%of sodium starchgylcolate and 30%of papaya pulp powder showed good disintegration and dissolution characteristics.Conclusion:Since the tablet formulation P7 containing 30%of papaya pulp powder shows good disintegration and dissolution characteristics and also falls with in the limits of other tablet evaluation parameter,it justifies the possible use of papaya pulp powder as a disintegrant in tablet formulation.The percentage of papaya pulp powder to be used could depend on the nature of the formulation and other excepients used along with it. Objective: the attempt was made to study the use of papaya pulp powder as a disintegrant in tablet formulations. The objective of the present work is to identify a natural binding and disintegrating agent for formulating tablets and to study the effect of disintegrating agents and binding agents On the dissolution of the table containing paracetamol.Methods:Papaya pulp powder was obtained from unripe papaya fruit.The fruit was screened for its physical and chemical characteristics and used in tablet formulations.In order to find out the percentage that could be used to formulate a product containing good disintegrating and conflict characteristics, several formulations(Paracetamol) with different concentrations of 8%,10%,12%,15%,20%,25%& 30%we prepared prepared.As a comparison,an already established disintegrant, Sodium starchgylcolate was selected and several formulated who similar ingredients,were also prepared.The invitro evaluation of the formulations were undertaken,and The results compared.In the present study assayulation studies on the purity, development of calibration curve of the drug and the compatibility between the drug and excepients were carried out.The fruits were cut into small pieces,grated,dried and powdered,passed through different Sieves and made into fine powder.Fine powder of papaya was mixed with required amount of drug and sodium starchgylcolate individually in different density along with other additives & binding agents.The dried granules were compressed into tablets and all the modified dosage forms of paracetamol tablets were Requirement to quality control tests like hardness disintegration and dissolution.Results:From the results it was observed that formulations S1 and P7 containing 8% of sodium starchgylcolate and 30% of papaya pulp powder showed good disintegration and solubility characteristics.Conclusion: Since the tablet formulation P7 containing 30% of papaya pulp powder shows good disintegration and dissolutionThe characteristics and also falls with in the limits of other tablet evaluation parameter,it justifies the possible use of papaya pulp powder as a disintegrant in tablet formulation.The percentage of papaya pulp powder to be used could depend on the nature of the formulation and other excepients Used along with it.