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本科遇到3例幼年型类风湿性关节炎(下称JRA),治疗时发生肝脏毒性反应,临床症状与Reye氏综合征(下称RS)相同,兹将典型病例简介如下。女性,3岁。因颈、双腕关节及双踝关节疼痛和肿胀20余天而入院。发病以来无明显发热,四肢活动有障碍、食欲减退。既往无特殊。体检:体温37℃,发育及营养稍差。颈部活动受阻,局部无压痛,双腕关节中度肿胀,活动明显障碍,双踝关节不肿,但有压痛及活动障碍。心肺未见异常。腹平软,肝右肋缘下1.5cm,脾未触及。神经系统无异常。血沉124mm/h,
Undergraduate encounter three cases of juvenile rheumatoid arthritis (hereinafter referred to as JRA), the treatment of liver toxicity occurred, the clinical symptoms and Reye’s syndrome (hereinafter referred to as RS), the typical cases are as follows. Female, 3 years old. Due to neck, wrist and double ankle joint pain and swelling more than 20 days and admitted to hospital. Since the onset of no significant fever, limb activity disorders, loss of appetite. No special past. Physical examination: body temperature 37 ℃, development and nutrition slightly worse. Neck activity blocked, no tenderness in the local, moderate swelling of the wrist, activity obvious obstacles, double ankle joint swelling, but tenderness and movement disorders. Heart and lung no abnormalities. Abdomen soft, liver right rib margin 1.5cm, spleen not touched. Nervous system no abnormalities. ESR 124mm / h,