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目的:探讨恶性血液病患者并发医院感染性败血症的临床特点。方法:对2000年1月至2005年12月间因患恶性血液病在我院住院治疗的198例患者的临床资料进行回顾性分析。结果:198例恶性血液病患者986次住院中共发生医院感染性败血症38例次,粒细胞缺乏组医院败血症发生率明显高于非粒细胞缺乏组(P<0.05),老年组高于非老年组(P<0.05)。感染病原菌以G-杆菌为主(73.2%),G-杆菌对亚胺培南敏感性最高(91.4%),G+球菌对万古霉素敏感性最好(99.6%)。结论:恶性血液病患者并发医院感染性败血症的发生率高,粒细胞缺乏和老年是恶性血液病并发医院感染性败血症的高危因素,应积极预防和早期合理治疗。
Objective: To investigate the clinical features of nosocomial infectious septicemia in patients with hematologic malignancies. Methods: The clinical data of 198 patients hospitalized with malignant blood diseases in our hospital from January 2000 to December 2005 were analyzed retrospectively. Results: A total of 38 cases of hospitalized sepsis occurred in 986 hospitalized cases of 198 cases of hematologic malignancies. The incidence of sepsis in hospitalized patients with agranulocytosis was significantly higher than that in non-neutropenic patients (P <0.05), higher in the elderly group than in the non-elderly group (P <0.05). The main pathogens were G-bacilli (73.2%), G-bacteria was the most sensitive to imipenem (91.4%), and Gococcus was the most sensitive to vancomycin (99.6%). Conclusions: The incidence of nosocomial infectious septicemia in patients with hematologic malignancies is high. Neutropenia and elderly patients are the risk factors of nosocomial infectious sepsis associated with hematologic malignancies. Therefore, they should be actively prevented and treated early.