Alzheimer\'s disease (AD) is the most common neurodegenerative disorder and is characterized pathologically by the progressive intracellular accumulation of neurofibrillary tangles and extracellular deposition of plaques in the brain.Since hyperphosphorylated tau and β-amyloid (Aβ) are respectively the major components of the tangles and the plaques,recent studies have mainly focused on the alterations associated with these two molecules.Clinically,AD features memory deterioration.More than 6 million patients in China alone are suffering from this devastating disease,and this figure is increasing with the acceleration of population ageing.Although many specific aspects of AD have been documented,the disease is hard to diagnose in the early stage and the efficacy of current treatments is very limited.Therefore,AD is attracting worldwide attention.