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配制了2种含有盐酸布比卡固的无痛,硫酸庆大霉素注射液,Ⅰ号液与Ⅱ号液(不加与加无水亚硫酸钠)。2种溶液经100℃水浴加热1h 与10h 或连续4次121℃加热30min,用微生物法测定硫酸庆大霉素含量,结果证明盐酸布比卡固与无水亚硫酸钠不影响庆大霉素的活性;无水亚硫酸钠的存在可克服硫酸庆大霉素固加热而引起的变黄现象。为减少肌肉注射时的疼痛,建议采用Ⅱ号液(加无水亚硫酸钠)处方进行注射液的生产。
Two kinds of painless, gentamicin sulfate injection, fluid I and fluid II (without addition of anhydrous sodium sulfite) were prepared with 2 bupivacaine hydrochloride. The two solutions were heated at 100 ℃ for 1h and 10h or four times at 121 ℃ for 30min. The gentamicin sulfate content was determined by the microbiological method. The results showed that bupivacaine hydrochloride and anhydrous sodium sulfite did not affect the activity of gentamicin The presence of anhydrous sodium sulfite can overcome the yellowing caused by gentamicin sulfate heating. In order to reduce the intramuscular injection of pain, it is recommended to use Ⅱ liquid (plus anhydrous sodium sulfite) prescription for injection production.