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目的观察利福喷丁治疗利福平低浓度耐药肺结核的疗效。方法将对利福平低浓度耐药肺结核杆茵阳性患者123例随机分为2组。观察组64例、对照组59例,分别用DEZThT和DEZThP方案治疗12个月。观察痰菌阴转、肺部病灶吸收及不良反应情况。结果痰菌阴转率:12月末观察组与对照组分别为43.8%和25.4%;胸部X线改善有效率:2组分别为53.1%和33.9%,2组比较差异均有统计学意义(均P<0.05)。结论临床上利福喷丁仍可用于对利福平低浓度耐药肺结核患者化疗方案中。
Objective To observe the efficacy of rifapentine in the treatment of low-concentration resistant rifampin-resistant pulmonary tuberculosis. Methods A total of 123 patients with positive sputum positive for rifampin in low concentration drug resistant pulmonary tuberculosis were randomly divided into two groups. 64 cases in the observation group and 59 cases in the control group were treated with DEZThT and DEZThP regimen for 12 months respectively. Observe sputum negative conversion, absorption of lung lesions and adverse reactions. Results The sputum negative conversion rate was 43.8% and 25.4% respectively in the observation group and the control group at the end of December. The improvement rate of the chest X-ray was 53.1% and 33.9% in the two groups respectively, with statistical significance (both P <0.05). Conclusions Rifampicin can still be used in the treatment of low-level drug-resistant pulmonary tuberculosis in patients receiving rifampicin.