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本文用动物实验和临床试验观察了通宣理肺口服液(LSL)对茶碱血药浓度的影响。动物实验:小鼠的氨茶碱剂量125mg/kg,口服液剂量25ml/kg,大鼠灌服氨茶碱剂量75mg/kg,灌服LSL20ml/kg。结果:小鼠实验组和对照组血茶碱血浓度分别为46.2±18.0μg/ml(n=13)和65.5±39.8μg/ml(n=13)。做两组均数t检验,t=1.60(t_(0.05)=2.064),统计学无显著性差别。大鼠实验组和对照组茶碱血浓度分别为47.6±17.4μg/ml(n=10),52.3±12.8μg/ml(n=10)。临床试验;选慢性阻塞性肺疾病病人14例,5男9女,年龄(59-74岁)。其中8例观察口服液对服用优喘平后茶碱血药浓度的影响。结果,8例中有3例血药浓度显著升高,3例升高,2例下降,做配对t检验,统计学上不够显著。另6例不见口服液对静点氨茶碱药浓度有影响。
This article used animal experiments and clinical trials to observe the effect of Tong Xuan Li Lung Oral Liquid (LSL) on the plasma concentration of theophylline. Animal experiments: The mice had an aminophylline dose of 125 mg/kg, an oral liquid dose of 25 ml/kg, a rat oral dose of aminophylline of 75 mg/kg, and an oral LSL of 20 ml/kg. RESULTS: Blood concentrations of hematin in the experimental and control groups were 46.2±18.0 μg/ml (n=13) and 65.5±39.8 μg/ml (n=13), respectively. Two groups of t-test were performed, t=1.60 (t_(0.05)=2.064). There was no significant difference in statistics. The concentrations of theophylline in the experimental and control groups were 47.6±17.4 μg/ml (n=10) and 52.3±12.8 μg/ml (n=10), respectively. Clinical trials; 14 patients with chronic obstructive pulmonary disease were selected, 5 males and 9 females, aged (59-74 years). Eight of them observed the effects of oral liquid on the plasma concentrations of post-opahimine in patients on asthma. As a result, plasma concentrations of 3 of 8 patients increased significantly, 3 patients increased, and 2 patients decreased. Paired t-tests were not statistically significant. The other 6 patients who did not see the oral solution had an effect on the concentration of the aminophylline drug.