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基于分子印迹技术的电化学发光分析是近几年刚刚发展起来的新型分析方法,兼具分子印迹技术与电化学发光方法两者的优点,具有高灵敏度、高选择性、可控性好、易于微型化和操作简单等特点,在生命科学、食品安全及环境监测等领域有着广泛的应用前景。本综述简要介绍了常用的电化学发光体系和基本原理,综述了近年来分子印迹电化学发光分析的主要研究进展,对不同类型分子印迹电化学分析的构建方法、原理及所构建方法的性能(包括灵敏度、选择性、检测范围和稳定性等)进行了评述。基于分子印迹技术的电化学发光分析主要可以分为三类:制备固态发光电极、非固态发光电极构建分子印迹电化学发光传感器和分子印迹固相萃取与电化学发光分析联用,其中制备固态发光电极用于构建分子印迹电化学发光传感器最有发展前景。最后,本综述也对分子印迹电化学发光分析今后的发展趋势和方向进行了展望。
Electrochemical luminescence analysis based on molecular imprinting technology is a new analytical method that has just been developed in recent years. It combines the advantages of both molecular imprinting and electrochemiluminescence. It has the advantages of high sensitivity, high selectivity, good controllability, Miniaturization and simple operation, etc. It has a wide range of applications in life sciences, food safety and environmental monitoring. This review summarizes the commonly used electrochemiluminescence systems and their basic principles. The main research progress of molecularly imprinted electrochemiluminescence (LIPA) in recent years is reviewed. The construction methods and principles of different types of molecular imprinted electrochemical analysis and the performance of the constructed method Including sensitivity, selectivity, detection range and stability, etc.). Electrochemical luminescence analysis based on molecular imprinting technique can be divided into three categories: preparation of solid state light-emitting electrode, non-solid state light-emitting electrode molecular imprinted electrochemical luminescence sensor and molecularly imprinted solid-phase extraction and electrochemical luminescence analysis, in which solid-state luminescence Electrodes are most promising for the construction of molecularly imprinted chemiluminescence sensors. Finally, the review also looks forward to the future trends and directions of molecularly imprinted chemiluminescence analysis.