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氯霉素是一种高效、广谱抗生素。它能有效地渗入脑脊液中,对于治疗多种细菌性脑膜炎有相当疗效。但是,由于氯霉素对造血系统的毒性颇为严重,因此监测体内氯霉素的浓度,可以指导临床安全用药,增强疗效,避免和减少毒副反应。 高效液相色谱法测定体内药物浓度,方法专一可靠,分析简便快速,国外近年来有应用于体液中氯霉素测定的报道。本文建立的测定人体脑脊液和血液中氯霉素含量的分析方法与上述报道比较,具有样品处理方便、流动相组成简单以及浓度测定线性范围广等特点,适用于临床体内药物浓
Chloramphenicol is a highly effective, broad-spectrum antibiotic. It can effectively penetrate the cerebrospinal fluid, for the treatment of a variety of bacterial meningitis has a considerable effect. However, due to the toxicity of chloramphenicol to the hematopoietic system is quite serious, monitoring the concentration of chloramphenicol in the body can guide clinical safe medication, enhance the curative effect, and avoid and reduce side effects. HPLC method for the determination of drug concentration in vivo, the method is reliable, the analysis is simple and quick. In recent years, foreign countries have reported the determination of chloramphenicol in body fluids. The established method for the determination of chloramphenicol in human cerebrospinal fluid and blood, compared with the above reports, has the advantages of convenient sample processing, simple mobile phase composition and linear range of concentration determination. It is suitable for clinical in vivo drug concentration