目的 :研究尼美舒利 (Nimesulide)合用 5 -Fluorouracil(5 -FU)对人胃癌细胞株BGC -82 3的生长抑制作用 ,判断联合用药的效果。方法 :采用MTT法、中效原理等测定药物的体外杀伤作用 ,进行联合用药分析。结果 :尼美舒利合用 5 -FU能显著抑制BGC -82 3的生长 ,当抑制率为 10 -95 %时 ,两药合用时合用指数 (CI) <1,为协同作用 ,使用药浓度减少 1-10倍。结论 :尼美舒利联合 5 -FU能显著增加单用其中一种药物对人胃癌细胞株BGC -82 3的抑制作用 ,两药联合应用时具有较好的协同作用。 OBJECTIVE: To study the inhibitory effect of Nimesulide combined with 5-Fluorouracil (5 -FU) on the growth of human gastric cancer cell line BGC-82 3 to determine the effect of combination therapy. Methods: MTT assay, the principle of efficiency and other drugs in vitro determination of the killing effect, the combination of drug analysis. Results: Nimesulide combined with 5 -FU significantly inhibited the growth of BGC-82 3. When the inhibition rate was 10 -95%, the combination index (CI) <1 for both drugs was synergistic, and the drug concentration was decreased 1-10 times. Conclusion: Nimesulide combined with 5 -FU can significantly increase the inhibition of human gastric cancer cell line BGC-82 3 with one of the two drugs alone. The combination of the two drugs has good synergistic effect.