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目的观察绞股蓝对实验性雄性小鼠一过性高尿酸血症的作用。方法将60只雄性小鼠随机分成6组,生理盐水组、模型组、对照组、绞股蓝大剂量组、绞股蓝中剂量组、绞股蓝小剂量组,分别以生理盐水、别嘌醇片和绞股蓝灌胃,连续10d。末次给药后,除生理盐水组外其余组腹腔注射次黄嘌呤0.63g/kg造模,之后测定小鼠血尿酸值及小鼠肝脏XOD的活性。结果血尿酸水平和肝脏组织XOD活性:绞股蓝中剂量组、别嘌呤醇组与模型组比较,差异均有非常显著性意义(P<0.01)。结论绞股蓝对小鼠一过性高尿酸血症具有明显降低血尿酸水平的作用。
Objective To observe the effect of Gynostemma on transient hyperuricemia in experimental male mice. Methods Sixty male mice were randomly divided into 6 groups: normal saline group, model group, control group, high dose of Gynostemma pentaphyllum, middle dose of Gynostemma pentaphyllum and low dose group of Gynostemma were administered with saline, allopurinol and Gynostemma For 10 days. After the last administration, except the saline group, the other groups were given intraperitoneal injection of hypoxanthine 0.63 g / kg, and then the blood uric acid level and the activity of mouse liver XOD were measured. Results Serum uric acid levels and liver tissue XOD activity: Gypenosides medium dose group, allopurinol group compared with the model group, the difference was significant (P <0.01). Conclusion Gynostemma had transient hypoglycemic effect on serum uric acid levels in mice.