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本文报告11例慢性气管炎病例肺泡壁的超微结构变化,其中7例并发肺气肿,5例并发肺心病。肺泡壁主要的病变有三:(1)肺泡上皮细胞的损伤和再生;(2)毛细血管基底膜增厚、内皮细胞损伤、血栓形成和管腔纤维化、闭塞;(3)肺泡壁纤维间质弥漫增生。这些病变在慢性气管炎并发肺气肿、肺心病的病例更为显著。其中毛细血管的病变、间质的弥漫纤维化与肺气肿、肺心病的成因关系密切。初步认为第Ⅲ型变态反应可能是引起上述病变的一个重要的因素。
This paper reports 11 cases of chronic bronchitis alveolar wall ultrastructure changes, including 7 cases of emphysema complicated by pulmonary heart disease in 5 cases. There are three main pathological changes in the alveolar wall: (1) alveolar epithelial cell injury and regeneration; (2) capillary basement membrane thickening, endothelial cell injury, thrombosis and luminal fibrosis, occlusion; (3) alveolar wall fibrosis Diffuse hyperplasia. These lesions in chronic bronchitis complicated by emphysema, pulmonary heart disease more significantly. One capillary lesions, interstitial diffuse fibrosis and emphysema, pulmonary heart disease is closely related to the cause. Preliminary believe that type Ⅲ allergic reaction may be caused by the above lesions is an important factor.