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本文对65例不同类型冠心病急性缺血发作患者、20例冠心病静止型患者和44例健康者血浆5-羟色胺(5-HT)、5-羟吲哚乙酸、去甲肾上腺素、多巴胺的含量进行测定。结果显示,心肌缺血发作者的这些含量均显著高于冠心病静止型者和正常人(P<0.001)。5-HT在AMI患者中最高,其次为不稳定型心绞痛、稳定型心绞痛者,AMI发病后5-HT即升高,第7天降至冠心病静止型水平,AMI死亡者5-HT水平显著高于生存者。提示5-HT测定有助于了解心肌缺血发作,并能为临床预防和治疗提供参考。
In this paper, 65 patients with different types of acute ischemic attack of coronary heart disease, 20 patients with quiescent coronary heart disease and 44 healthy subjects plasma 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid, norepinephrine, dopamine Content was measured. The results showed that these factors were significantly higher in patients with myocardial ischemia than those with silent and normal coronary heart disease (P <0.001). 5-HT was the highest in patients with AMI, followed by unstable angina and stable angina, 5-HT increased after AMI onset, dropped to the resting level of coronary heart disease on the 7th day, and the 5-HT level was significantly lower in AMI patients Above the survivors. Tip 5-HT assay can help understand the onset of myocardial ischemia, and can provide a reference for clinical prevention and treatment.