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目的探讨TRB3 Q84R基因多态性与不同表型多囊卵巢综合征(Ⅰ型:O+H+P;Ⅱ型:O+H;Ⅲ型:H+P;Ⅳ型:O+P)的相关性。方法采用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restriction frag-ment length polymorphism,PCR-RFLP)方法检测TRB3 Q84R的基因多态性。结果 TRB3 Q84R基因型频率分布在Ⅰ型P-COS组(O+H+P)与对照组之间有显著性差异(P<0.05);其余PCOS表型与对照组之间基因型频率分布无显著性差异(P>0.05)。结论 TRB3 Q84R基因多态性与Ⅰ型PCOS相关。
Objective To investigate the association of TRB3 Q84R polymorphism with polycystic ovary syndrome (type Ⅰ: O + H + P; type Ⅱ: O + H; type Ⅲ: H + P; type Ⅳ: O + P) Sex. Methods The gene polymorphism of TRB3 Q84R was detected by polymerase chain reaction-restriction fragmentation length polymorphism (PCR-RFLP). Results The distribution of genotype frequency of TRB3 Q84R was significantly different between the type Ⅰ P-COS group (O + H + P) and the control group (P <0.05). The genotype frequencies of other PCOS phenotypes were not significantly different from those of the control group Significant difference (P> 0.05). Conclusion The polymorphism of TRB3 Q84R gene is associated with type Ⅰ PCOS.