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目前 ,淋巴瘤遗传学研究已取得了很大的进展 ,对认识其发病机制及临床分类均有重要的意义 ,本文就胃 MAL T淋巴瘤遗传学研究作一概括 ,阐述了 API2 - MAL T1融合基因及 Bcl1 0基因易位等新的研究进展 ,探讨了 Hp依赖、非依赖性淋巴瘤与遗传学异常之间的关系 ,对胃 MAL T淋巴瘤如何从依赖抗原生长转变为自主生长的分子机制、如何引起组织学转化的分子机制及其与临床分期、分级、治疗的关系有了初步了解 ,有利于指导胃 MAL T淋巴瘤的治疗
At present, great progress has been made in the study of lymphoma genetics, which is of great significance in understanding the pathogenesis and clinical classification of lymphoma. In this article, we summarize the research on the genetics of gastric MAL T lymphoma, and describe the API2 - MAL T1 fusion Gene and the Bcl10 gene translocation and other new research progresses to explore the relationship between Hp-dependent, non-dependent lymphoma and genetic abnormalities, gastric MAL T-lymphoma on how to switch from the antigen-dependent growth to molecular mechanisms of independent growth , How to cause the molecular mechanism of histological transformation and its clinical staging, grading, treatment has a preliminary understanding of the relationship will help guide the treatment of gastric MAL T lymphoma