目的探讨高效抗反转录病毒治疗(HAART)联合冰火两重灸法,在治疗艾滋病病毒(HIV)感染者/AIDS病人(简称HIV/AIDS病人)时对肝功能的影响。方法选择62例HIV/AIDS病人,试验组和对照组各31例,观察两组的肝功能指标:丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)的变化。结果试验组(即HAART联合冰火两重灸组)和对照组(单纯HAART组)病例入组前在年龄和AST、ALT指标上差异均无统计学意义。试验组的病人治疗第3个月AST/ALT升高,其比例为22.58%,第6个月为38.71%,均低于对照组的54.84%及64.52%水平,两者差异有统计学意义(P<0.05);两组病人在起始HAART治疗后6个月均以AST指标升高为主,且在两组间差异有统计学意义(P<0.05),而在ALT指标上试验组低于对照组,但两组差异无统计学意义(P>0.05)。结论中医灸法可明显降低HAART药物引起肝损伤的发生率,但其作用机制有待进一步研究。 Objective To investigate the effect of HAART combined with ice-fire double-moxibustion on liver function in the treatment of HIV / AIDS patients (HIV / AIDS patients for short). Methods Totally 62 cases of HIV / AIDS patients, 31 cases in experimental group and control group were selected. The indexes of liver function, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were observed. Results There was no significant difference in age, AST and ALT before trial between the two groups (HAART combined with ice-fire group) and the control group (HAART group). The AST / ALT increased in the third month after treatment in the experimental group (22.58%) and 38.71% (6th month), both of which were lower than the 54.84% and 64.52% of the control group P <0.05). Both groups were mainly elevated in AST at 6 months after initial HAART treatment, and there was a significant difference between the two groups (P <0.05) In the control group, but there was no significant difference between the two groups (P> 0.05). Conclusion Chinese medicine moxibustion can significantly reduce the incidence of HAART induced liver injury, but its mechanism needs further study.