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目的探讨哮喘儿童急性发作期血镁、尿镁、红细胞内镁离子的浓度变化,了解尿镁在判断低镁缺乏症中的意义。方法观察组为自2001年9月至2004年12月浙江省东方医院以及鄂州市中心医院就诊的哮喘急性发作期患儿100例,年龄3~14岁;对照组为同时期、相同年龄段的托幼机构、学校健康儿童80例。2组研究对象均取静脉血3mL、同时收集24h尿,记录尿量。全自动生化分析仪检测血镁、血钙,尿镁、尿肌酐和红细胞内镁浓度。结果观察组尿镁、红细胞内镁浓度明显低于对照组(P<0·001);两组儿童血镁、血钙差异无显著性(P>0·05)。结论儿童哮喘在急性发作期会合并镁缺乏症,尿镁浓度测定是判断是否有镁离子缺乏的简单、有效方法,血浆镁浓度不能作为衡量体内镁离子平衡的一个可靠指标。
Objective To investigate the concentration changes of magnesium, magnesium and erythrocytes in acute asthma children and to understand the significance of urinary magnesium in judging low magnesium deficiency. Methods The observation group was 100 cases of children with acute exacerbation of asthma who were treated at Zhejiang Dongfang Hospital and Ezhou Central Hospital from September 2001 to December 2004, and were aged from 3 to 14 years old. The control group was in the same period and same age group Nurseries, school health children 80 cases. Two groups of patients were given venous blood 3mL, while collecting 24h urine, urine output. Automatic biochemical analyzer detection of blood magnesium, blood calcium, urinary magnesium, urinary creatinine and intrarenal magnesium concentration. Results The levels of urinary magnesium and erythrocyte magnesium in the observation group were significantly lower than those in the control group (P <0.001). There was no significant difference in serum magnesium and serum calcium between the two groups (P> 0.05). Conclusions Childhood asthma may be associated with magnesium deficiency during acute exacerbation. Determination of urinary magnesium concentration is a simple and effective method to determine whether there is lack of magnesium ions. Plasma magnesium concentration can not be used as a reliable indicator to measure magnesium ion balance in vivo.