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宫颈癌是常见的女性恶性肿瘤,其发生发展与HPV的感染密切相关。HPV16是宫颈癌患者中感染率最高的亚型,其编码的早期蛋白E5、E6、E7可刺激宫颈上皮细胞转化成肿瘤细胞。E6、E7蛋白在宫颈癌晚期表达,E5可能在早期表达。E5蛋白的是否表达及其致癌机制与多种因子相关。E5蛋白可作用于细胞生长因子受体通路,下调miRNA196a,并通过与HLAⅠ类分子结合协助感染细胞免疫逃逸,从而促进肿瘤的发生。E5蛋白与E6、E7蛋白协同会发挥更强的致宫颈癌作用。本研究对E5蛋白表达与病毒整合的关系及其对宫颈癌的作用进行了综述。
Cervical cancer is a common female malignant tumor, its occurrence and development are closely related to HPV infection. HPV16 is a subtype with the highest infection rate in cervical cancer patients. The encoded early proteins E5, E6 and E7 stimulate cervical epithelial cells to transform into tumor cells. E6, E7 protein expression in advanced cervical cancer, E5 may be expressed in the early. E5 protein expression and its carcinogenic mechanism and a variety of factors. E5 protein can act on the cell growth factor receptor pathway, down-regulate miRNA196a, and through the combination of HLA class I molecules to help immune cells escape immune escape, thereby promoting tumorigenesis. E5 protein and E6, E7 protein synergy will play a stronger role in cervical cancer. This study summarized the relationship between E5 protein expression and virus integration and its effect on cervical cancer.