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NIH系小鼠灌服司帕沙星,口服剂量分别为250、1000和2500mg/kg时微核发生率在5‰以下,试验结果与空白对照相似判为阴性。
NIH mice fed sparfloxacin, oral doses of 250,1000 and 2500mg / kg micronucleus incidence of 5 ‰ or less, the test results were negative as similar to the blank control.