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目的:探究桔梗皂苷对烟雾致矽肺患者血清白介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)水平的影响。方法:选取我院呼吸科2012年6月到2013年6月收治的68例男性矽肺患者,并将其随机分为2组。对照组34例,给于矽肺宁片4片/次,3次/d,口服;氨茶碱片0.1 g/次,3次/d,口服;必漱平片16 mg/次,3次/d,口服;舒喘灵片4.8 mg/次,3次/d,口服;疗程24周。实验组34例,在常规治疗的基础上应用加用桔梗皂苷胶囊10 g/次,3次/d,口服;疗程24周。治疗结束后,检测和比较治疗前后两组患者SaO2、PaO2、Pa CO2、血清IL-8和TNF-α的变化情况。结果:治疗后,两组患者的SaO2、PaO2、Pa CO2水平均得到改善,实验组以上指标较改善更为显著,差异具有统计学意义(P<0.05)。治疗后,两组患者的IL-8和TNF-α水平均较治疗前显著下降,且实验组IL-8和TNF-α水平显著低于对照组,差异具有统计学意义(P<0.05)。结论:桔梗皂苷辅助治疗能够显著改善烟雾致矽肺患者的呼吸功能,降低血清IL-8和TNF-α含量。
Objective: To investigate the effect of Platycodin on the levels of serum interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in smokers with silicosis. Methods: Sixty-eight male silicosis patients admitted to our hospital from June 2012 to June 2013 were selected and randomly divided into two groups. The control group of 34 patients were given 4 tablets of silicotinine once daily for 3 times daily, aminophylline tablets 0.1 g once daily for 3 times daily, , Orally; Shucu Ling tablets 4.8 mg / time, 3 times / d, oral; course of 24 weeks. The experimental group of 34 cases, on the basis of routine treatment with the application of platyclada capsules 10 g / times, 3 times / d, oral; treatment for 24 weeks. After treatment, the changes of SaO2, PaO2, PaCO2, serum IL-8 and TNF-α in two groups before and after treatment were detected and compared. Results: After treatment, SaO2, PaO2 and Pa CO2 levels in both groups were improved. The above indexes in the experimental group improved more significantly than those in the experimental group, with statistical significance (P <0.05). After treatment, the levels of IL-8 and TNF-α in both groups were significantly lower than those before treatment, and the levels of IL-8 and TNF-α in the experimental group were significantly lower than those in the control group (P <0.05). Conclusion: Paclitaxel-assisted adjuvant therapy can significantly improve the respiratory function and reduce the levels of serum IL-8 and TNF-α in smokers with silicosis.