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利用牛血清白蛋白为材料,制备了苦参素白蛋白微球。该微球直径小于2 μm,含有苦参素 2.14%。体外实验证实,在 pH 7.4的 0.1mol/ L磷酸盐缓冲液中缓释作用明显,符合一级释放机理。
Bovine serum albumin microspheres were prepared using bovine serum albumin as material. The microspheres have a diameter of less than 2 μm and contain oxymatrine 2.14%. In vitro experiments confirmed that the sustained-release effect in 0.1 mol/L phosphate buffer at pH 7.4 was obvious and met the first-order release mechanism.