【摘 要】
：
The effects of low ratio of n-6/n-3 polyunsaturated fatty acids(PUFA)have been clarified against atherosclerosis.Increasing evidence indicated that plant sterols(PS)have a significant cholesterol-lowering effect.This study explored the effects of PS combi
【机 构】
：
Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science an
论文部分内容阅读
The effects of low ratio of n-6/n-3 polyunsaturated fatty acids(PUFA)have been clarified against atherosclerosis.Increasing evidence indicated that plant sterols(PS)have a significant cholesterol-lowering effect.This study explored the effects of PS combined with n-6/n-3(2:1)PUFA on atherosclerosis and investigated the possible mechanism.In ApoE-/-mice,the milk fat in high fat diets was replaced with n-6/n-3(2:1)PUFA alone or supplemented with 6％PS for 16 weeks.Results demonstrated that PS combined with PUFA exerted commentary and synergistic effects on ameliorating atherosclerosis,improving lipid metabolism and lipid deposition in liver,and alleviating inflammatory response.These changes were accompanied with decreased serum TC,TG,LDL-C and increased fecal cholesterol efflux,as well as the lower inflammatory cytokine CRP,IL-6,TNF-a.It is suggested that the underlying mechanism of PS combined with n-6/n-3(2:1)PUFA promoting the fecal cholesterol efflux may be mediated by liver X receptor a/ATP-binding cassette transporter Al pathway.
其他文献
Abundant studies have been conducted to identify how B-cell translocation gene 1 protein(BTG1)gene affects the differentiation,proliferation,metastasis of cancer cells,and how it further regulates the generation or development of diseases to influence the
Mechanisms of pruritus are implicated in the dysregulation of the metabolites in the spinal cord.We investigated pruritus behavioral testing in three groups of young adult male C57B1/6 mice,including one group treated with normal saline,while the other gr
Studies on the integration of cross-modal information with taste perception has been mostly limited to uni-modal level.The cross-modal sensory interaction and the neural network of information processing and its control were not fully explored and the mec
Fibulin-1(FBLN-1),an elastin-associated extracellular matrix protein,has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease(CVD).We aimed to investigate the relationship between fibulin-1 levels a
Microsurgical free tissue transfer is still playing an important role in lower extremity reconstruction.Finding a suitable recipient artery for anastomosis is critical in the microsurgical procedure,especially in an extensive wound,or in a complex trauma
通过夏比冲击和示波冲击方法分析了两种Ce含量S32750超级双相不锈钢在20～-100℃范围内的冲击吸收能量及能量构成差异,利用Aspex自动扫描电镜分析仪、SEM、EDS研究了Ce对钢中夹杂物的改性行为及冲击断裂行为的影响.结果表明:高Ce试验钢的抗低温冲击断裂性能明显优于低Ce试验钢,前者韧脆转变温度相较后者下降16℃;Ce的添加使得试验钢-80℃冲击吸收能量提高45 J,其主要源于裂纹扩展能Wp的提升(76％).冲击断口形貌观察和夹杂物分析结果显示,低Ce试验钢在-80℃冲击断口表现为完全解理断裂;
Studies have shown that periodontal pathogens can enter the bloodstream,causing a series of reactions that can lead to a variety of systemic diseases.Epidemiological investigations also found a tight correlation between periodontitis(PD)and osteoporosis.T
Constructing two-dimensional (2D) layered materials with traditional three-dimensional (3D) semiconductors into complex heterostructures has opened a new platform for the development of optoelectronic devices. Herein, large-area high performance self-driv
以一种屈服强度为1100 MPa的高强度工程机械用钢为对象,研究了再加热淬火温度(880～980℃)和回火温度(200～650℃)对Q1100钢显微组织和力学性能的影响.结果表明,淬火温度从880℃升高至980℃,试验钢的平均奥氏体晶粒尺寸从8μm增加到24μm,试验钢的屈服强度和抗拉强度都呈先升高后降低的趋势,并在920℃时达到最大,而-40℃冲击性能则随之持续降低.试验钢经920℃淬火+200～650℃回火后,随着回火温度的提高,试验钢的马氏体板条合并,板条形貌逐渐模糊,碳化物数量和形貌也随之发生改变
通过光学显微镜、室温拉伸试验、显微硬度计、X射线衍射仪、扫描电镜等方法研究了累积叠轧温度对AZ31镁合金晶粒尺寸、基面织构、界面结合情况及力学性能的影响.结果表明:3道次累积叠轧后的AZ31镁合金晶粒细化效果明显,硬度增大,随着累积叠轧温度的升高,晶粒细化效果减弱,硬度增加趋势减弱.累积叠轧温度升高有弱化基面织构的作用.AZ31镁合板材在450℃累积叠轧3道次,综合力学性能最佳,为显微硬度70.64 HV0.05,抗拉强度288.64 MPa,屈服强度203.76 MPa,伸长率16.96％,界面结合强度