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目的:研究16,16-二甲基前列腺素E2(dnaPGE2)和γ-干扰素(IFN-γ)的抗肝纤维化作用。方法:以二甲基亚硝胺(DMN)腹腔注射诱导大鼠肝纤维化模型.染毒开始及染毒后5周分别用dmPGE2和IFN-γ预治疗和治疗肝纤维化。与正常及染毒组比较,观察各组病理及肝纤维化程度。结果:dmPGE2预治疗和治疗组纤维化程度与IFN-γ组相近,且明显小于染毒对照组,肝羟脯氨酸(HyP)血清透明质酸(HA)较染毒组明显降低。结论:dmPGE2有较好的抗肝纤维化作用。
Objective: To investigate the anti-hepatic fibrosis effects of 16,16-dimethyl prostaglandin E2 (dnaPGE2) and interferon-γ (IFN-γ). Methods: The model of hepatic fibrosis induced by intraperitoneal injection of dimethylnitrosamine (DMN) was induced in rats, and hepatic fibrosis was pretreated and treated with dmPGE2 and IFN-γ at the beginning of exposure and 5 weeks after exposure to DMN. Compared with the normal and exposure groups, the pathological changes and the degree of liver fibrosis were observed. Results: Compared with IFN-γ group, the degree of fibrosis in pre-treated and dmPGE2-treated groups was significantly lower than that in control group, and the serum hyaluronic acid (HA) of hypohydroxy-proline (HyP) Conclusion: dmPGE2 has better anti-hepatic fibrosis effect.