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目的分析血清白介素-4在幼儿喘息性疾病中的表达水平与诊断价值。方法选取该院2014年1月-2015年6月收治的幼儿喘息性疾病患儿100例,对患儿治疗后期进行随访,依据患儿的喘息发生状况分为喘息A组(n=42)与喘息B组(n=58),另选取同年龄正常儿童30例为对照组。比较3组血清IL-4水平。结果喘息A组与喘息B组患儿急性期血清IL-4水平均高于对照组(P<0.05),且喘息A组血清IL-4水平高于喘息B组,差异有统计学意义(P<0.05);喘息A组与喘息B组患儿恢复期血清IL-4水平均显著下降(P<0.05),但喘息A组高于喘息B组(P<0.05),2组均高于对照组(P<0.05)。喘息A组患儿API阳性率显著高于喘息B组患儿(P<0.05)。结论幼儿喘息性疾病患儿血清IL-4水平持续升高,是导致患儿发展为持续性喘息的主要原因之一,早期对患儿进行检测血清IL-4水平,对鉴别患儿是否发展成持续性喘息具有重要诊断价值。
Objective To analyze the expression and diagnostic value of serum interleukin-4 in asthmatic children. Methods A total of 100 children with asthmatic asthma admitted to our hospital from January 2014 to June 2015 were enrolled in this study. Patients were followed up for later treatment. Patients were divided into asthmatic group A (n = 42) and asthmatic group Wheezing group B (n = 58), and the other 30 normal children of the same age as the control group. The levels of serum IL-4 in the three groups were compared. Results The serum levels of IL-4 in patients with wheezing group A and wheezy group B were significantly higher than those in control group (P <0.05), and the serum IL-4 level in wheezing group A was higher than that in wheezing group B (P <0.05). Serum IL-4 levels in convalescent group A and group B were significantly lower than those in group B (P <0.05), but group A was higher than group B Group (P <0.05). The positive rate of API in wheezing group A was significantly higher than that in wheezing group B (P <0.05). Conclusions Children with wheezing diseases continue to have elevated serum IL-4 levels, which is one of the main causes of persistent wheezing in children. Early detection of serum IL-4 levels in children may be helpful in differentiating children from developing into Persistent wheezing has important diagnostic value.