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巯甲丙脯酸(Captopril,CPT),化学名称为D-3-巯基-2甲基丙酰-L-脯氨酸,是活性强特异性高的血管紧张素转换酶(ACE)竞争性抑制剂,对各型高血压具有显著降压作用,亦能改善慢性充血性心衰(CHF)的心功能,现国内应用日趋广泛。一、CPT治疗高血压的临床应用 CPT通过抑制肾素-血管紧张素-醛固酮(RAA)系统起作用。肾素作用于血管紧张素原产生血管紧张素I(AI),AI在肺循环中ACE的作用下,转化为血管紧张素II(AII),AII使小动脉和前毛细血管收缩,使循环阻力升高,并刺激醛固酮分泌,导致钠水潴留,最终引起血压升高。虽然目前对高血压的确切发病机理不十分清楚,但RAA在各型高血压所起的作用
Captopril (CPT), a chemical name of D-3-mercapto-2-methylpropionyl-L-proline, is a highly active and specific inhibitor of angiotensin converting enzyme (ACE) competitive inhibition Agent, has a significant antihypertensive effect on various types of hypertension, can also improve the heart function of chronic congestive heart failure (CHF), is now widely used in China. First, the clinical application of CPT in the treatment of hypertension CPT through the inhibition of renin - angiotensin - aldosterone (RAA) system. Renin acts on angiotensinogen to produce angiotensin I (AI). AI converts to angiotensin II (AII) under the action of ACE in the pulmonary circulation. AII contracts the arterioles and pre-capillaries, resulting in a rise in circulating resistance High, and stimulate the secretion of aldosterone, resulting in sodium and water retention, eventually causing high blood pressure. Although the exact pathogenesis of hypertension is not well understood, the role of RAA in various types of hypertension