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核转录因子κB(NF-κB)不仅能调节多种基因的表达和产生细胞因子,还能调节多种炎症因子的表达和细胞凋亡,炎症反应的许多分子都受NF-κB的调控,包括:TNF-α、IL-1β、IL-2、IL-6、趋化因子、黏附分子、集落刺激因子等。文章从NF-κB的化学生物学特性及其信号通路、NF-κB在系膜细胞中的表达以及诱发膜增生性肾小球肾炎的机制、中医药对NF-κB表达影响的研究进展等方面加以论述,分析了NF-κB在膜增生性肾小球肾炎中所起的作用及中医药对它的调节作用,指出中医药拮抗NF-κB的表达,可能是中医药作用的主要靶点之一。
Not only does NF-κB regulate the expression of many genes and produce cytokines, but also regulate the expression of many inflammatory factors and apoptosis, many molecules of inflammatory response are regulated by NF-κB, including : TNF-α, IL-1β, IL-2, IL-6, chemokines, adhesion molecules, colony stimulating factors and the like. The article from the chemical and biological characteristics of NF-κB and its signaling pathway, the expression of NF-κB in mesangial cells and induce the mechanism of membranoproliferative glomerulonephritis, traditional Chinese medicine on the impact of NF-κB research progress It is discussed that the role of NF-κB in membranoproliferative glomerulonephritis and its regulation by Chinese medicine have been analyzed. It is pointed out that the antagonism of NF-κB by Chinese medicine may be the main target of traditional Chinese medicine one.