泛发性硬皮病的发病机理至今未明,因而其药物疗法虽有多种,但疗效不一。作者于1975年使用人胎盘提取物治疗本病收到良好的临床效果。用药对象及方法:用药对象是本科收治的泛发性硬皮病(硬化～萎缩期)患者共25例。其中男性4例,女性21例,初诊年龄不到29岁者7例,30～39岁6例,40～49岁9例,50岁以上3例。各例的临床症状及临床检查结果如表。所用的药物为PLP~R(是一种人胎盘提取物的商品药名),原则上每日1安瓿,肌内注射,每一病例投药2～9个月。疗效判定标准:泛发性硬皮病患者的临床症状和临床检查结果并非一律的。因而药物的疗效判定不得不根据自觉症状的变化,医生对皮肤硬化、色素增多等的判断,并参考手指的自记温度计象及尿中粘多糖的质的变化。 The pathogenesis of generalized scleroderma is still unknown, so its drug therapy although a variety, but different effects. The authors received good clinical results in the treatment of this disease using human placenta extract in 1975. Drugs and methods of treatment: The subjects were admitted to the generalized patients with scleroderma (sclerosis ~ atrophy) a total of 25 patients. There were 4 males and 21 females. Seven cases were younger than 29 years old, 6 cases were from 30 to 39 years old, 9 cases were from 40 to 49 years old and 3 cases were over 50 years old. Cases of clinical symptoms and clinical examination results as shown in the table. The drug used is PLP-R, a commercially available product of human placenta extract. In principle, 1 ampoule per day is injected intramuscularly for 2 to 9 months in each case. Efficacy criteria: clinical manifestations of patients with generalized scleroderma and clinical examination results are not uniform. Therefore, the efficacy of drugs have to judge based on changes in subjective symptoms, the doctor on the skin sclerosis, pigmentation and other judgments, and refer to finger self-remember thermometer and urine mucopolysaccharide qualitative changes.