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目的观察恒河猴对麻疹-流行性腮腺炎(流腮)-流行性乙型脑炎(乙脑)联合减毒活疫苗(Measles,Mumps and Japanese Encephalitis Combined Attenuated Live Vaccine,M-M-JEV)的神经毒力产生及其严重程度,对M-M-JEV进行安全性评价。方法猴两侧丘脑和腰髓内注射M-M-JEV,同时设阴性对照和麻疹减毒活疫苗、乙脑减毒活疫苗及麻疹-流腮联合减毒活疫苗对照,观察临床症状,并检查注射部位、体温、血液学、血液生物化学、摄食量、眼科学以及血清抗体等变化情况;实验结束进行大体病理学和组织病理学检查。结果各项观察指标及检查结果均与对照疫苗或阴性对照相似,相关数据与对照疫苗或阴性对照组比较差异均无统计学意义。结论 M-M-JEV表现出与单价疫苗或相关联合疫苗相似的安全性。
Objective To observe the effects of rhesus monkeys on the neurons of Measles, Mumps and Japanese Encephalitis Combined Attenuated Live Vaccine (MM-JEV) with measles-mumps (Mumps) - Japanese encephalitis (JE) Virulence and its severity, the safety evaluation of MM-JEV. Methods MM-JEV was injected into the thalamus and spinal cord on both sides of the monkey. At the same time, negative control and attenuated live attenuated measles vaccine, live attenuated JE vaccine and live attenuated measles-vaginal gavage vaccine were given. The clinical symptoms were observed and injected Location, body temperature, hematology, blood biochemistry, food intake, ophthalmology and serum antibody changes; the end of the experiment for gross pathology and histopathological examination. Results The results of the observation and test results were similar to the control vaccine or negative control, the data were not significantly different from the control vaccine or negative control group. Conclusions M-M-JEV shows similar safety to monovalent or associated vaccine.