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提出了氟哌酸原料药中微量脱羧物作为杂质6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)喹啉(1)产生的另一途径是:7-氯-6-氟-4-羟基喹啉-3-羧酸乙酯(2)乙基化时生成的副产物4被水解成羧酸5,5与哌嗪缩合的同时脱羧,生成1。并用~1HNMR方法测定了用不同烷化剂所得乙基化产物中4的含量。
An alternative route for the production of trace amount of decarboxylation of norfloxacin as impurity 6-fluoro-1,4-dihydro-4-oxo-7- (1-piperazinyl) quinoline (1) Production of Ethyl 7-Chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate (2) By-product 4 generated upon ethylation was hydrolyzed to carboxylic acid 5,5 Decarboxylated while condensing with piperazine to give 1 . The contents of 4 in the ethylated product obtained with different alkylating agents were measured by ~ 1HNMR method.