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为观察窒息缺氧对新生儿止血状态的影响，选择了凝血、抗凝、纤溶系统１２项指标对４１例足月窒息新生儿进行前瞻性研究，并与２１例正常足月新生儿比较。结果：窒息儿血小板计数、纤维蛋白原、抗凝血酶Ⅲ、纤溶酶原、纤溶酶、α２纤溶酶抑制物等指标均有不同程度降低，而血管性血友病因子（ｖＷＦ）、组织纤溶酶原激活物（ｔＰＡ）、纤溶酶原激活物抑制物－１（ＰＡＩ－１）、Ｄ二聚体等均有明显升高，可溶性纤维蛋白单体复合物９５％为阳性。血管内皮损伤标记物、ｖＷＦ、ｔＰＡ、ＰＡＩ－１与窒息儿血ｐＨ值呈负相关（ｒ＝－０．４７，Ｐ＜０．０１；ｒ＝－０．４６６，Ｐ＜０．０１；ｒ＝－０．３１４，Ｐ＜０．０５），且与窒息严重度一致。提示：窒息新生儿存在以高凝为主的早期ＤＩＣ，血管内皮损伤在窒息病理生理学中具重要作用。
In order to observe the effect of asphyxia and hypoxia on the hemostasis status of neonates, 12 indexes of coagulation, anticoagulation and fibrinolytic system were selected to prospectively study 41 newborns with full-term asphyxia and compared with 21 normal full-term newborns. Results: Thrombocytopenic index, fibrinogen, antithrombin Ⅲ, plasminogen, plasmin, α2 plasmin inhibitor and other indicators were reduced to varying degrees, and von Willebrand factor (vWF) , Tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), D dimer, etc. were significantly increased, 95% of soluble fibrin monomer complex was positive . Vascular endothelial injury markers, vWF, tPA, PAI-1 and asphyxia children blood pH value was negatively correlated (r = -0.47, P <0.01; r = -0.466, P <0.01; r = -0.314, P <0.05), and consistent with the severity of asphyxia. Tip: asphyxia newborn hypercoagulability exist in the early DIC, vascular endothelial injury in asphyxia pathophysiology play an important role.