论文部分内容阅读
目的探讨鼻咽未分化癌患者肿瘤组织中LKB1蛋白表达情况及其在放疗中应用的临床意义。方法采用免疫组织化学SP法检测65例鼻咽未分化癌患者肿瘤组织中LKB1蛋白表达情况,并依据检查结果将其分为阳性组和阴性组,记录2组年龄、性别比例、EB病毒阳性、远处转移情况,放疗结束后4周评定2组疗效,并随访观察2组3a生存率。结果 65例中鼻咽未分化癌组织LKB1阳性39例(阳性组),LKB1阴性26例(阴性组);阳性组颈部淋巴结转移率(38.46%)低于阴性组(69.23%)(P<0.05),2组年龄、性别比例、EB病毒阳性表达率比较差异无统计学意义(P>0.05);阳性组总有效率(71.79%)高于阴性组(46.15%)(P<0.05),3a生存率(58.97%)高于阴性组(26.92%)(P<0.05)。结论 LKB1蛋白与鼻咽未分化癌颈部淋巴结转移有关,LKB1阳性患者常规放疗疗效及远期预后优于LKB1阴性患者。
Objective To investigate the expression of LKB1 protein in tumor tissue of undifferentiated nasopharyngeal carcinoma and its clinical significance in radiotherapy. Methods Immunohistochemical SP method was used to detect the expression of LKB1 protein in 65 cases of undifferentiated nasopharyngeal carcinoma. According to the result of the examination, the expression of LKB1 protein was divided into positive group and negative group. Two groups of age and sex ratio, positive of EB virus, Distant metastasis, radiotherapy 4 weeks after the assessment of two groups of curative effect, and follow-up observed two groups 3a survival rate. Results The positive rate of cervical lymph node metastasis (38.46%) in positive group was lower than that in negative group (69.23%) (P < 0.05). There was no significant difference between the two groups in age, sex ratio and EBV positive rate (P> 0.05). The total effective rate in positive group (71.79%) was higher than that in negative group (46.15%) (P <0.05) 3a survival rate (58.97%) than the negative group (26.92%) (P <0.05). Conclusion LKB1 protein is associated with cervical lymph node metastasis in undifferentiated nasopharyngeal carcinoma. The conventional radiotherapy and long-term prognosis of LKB1-positive patients are superior to those of LKB1-negative patients.