患者女性,46岁。因双侧乳房肿块伴乳晕部溃疡1个半月于1994年7月入院。入院前两年内曾分别3次行左、右乳房肿块切除,病理检查均为“乳房纤维腺瘤”。1个半月前同时出现双乳肿块伴溃疡、溢液。无家族史。体查:一般情况尚好,心、肺、腹检查无异常。双侧乳房可见陈旧手术疤痕,肿块不规则,位双乳房中央、隆起,乳头、乳晕皮肤溃破,可见淡红色分泌物,周围皮肤数处岛状桔皮样改变。左右侧肿块分别为6cm×4cm×4cm、5cm×4cm×4cm,表面凹凸不平,边 Female patient, 46 years old. Due to bilateral breast lumps with areola ulcers, one and a half months were admitted in July 1994. The left and right breast lumps were removed 3 times in the two years before admission, and the pathological examinations were all “breast fibroadenoma.” One and a half months ago, a double breast lumps developed with ulcers and discharge. No family history. Physical examination: The general situation is still good, heart, lung, abdomen check no abnormalities. There were old surgical scars on the bilateral breasts, irregular masses, central double breasts, bulge, nipple, areola skin ulceration, pale red discharge visible, and several orange peel-like changes around the skin. The left and right masses are 6cm×4cm×4cm and 5cm×4cm×4cm, respectively.